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KMID : 0362919850030020153
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1985 Volume.3 No. 2 p.153 ~ p.157
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Radiation Effect on Body Weight and Hematological Changes of Hybrid Mice by Conventional Fraction, Large Abdominal FieldIrradiation
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Lee Sung-Heon
Shin Sei-One
Kim Myung-Se
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Abstract
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Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ray. Various experimental animals were tried for radiobiological studies. 72 hybrid mice with conventional ffaction (5X/week), large abdominal field (2 ×3cm, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about 29.7% in male ; 30.4% in female at 6000 rad irradiation group. Hemoglobin value was nearly normal throughout entire treatment. Significant dropping of WBC count was noted to 40-50% of pretreatment values by only 1000 rad irradiation. Change of differential count was interesting; lymphocyte proportion showed gradual reduction, instead of gradual increasing of segmented neutrophil. Those proportion were reversed after 6000 rad irradiation. Urinary protein tests showed ＋ － ＋＋＋, showing no correlation with dosage. Application. of our study in clinical combination therapy (radiation ＋ chemotherapy) was discussed.
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KEYWORD
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Radiation effect, Hematologic changes, Large abdominal field
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